Cognitive and Social Impairment in Mouse Models Mirrors Dravet Syndrome
نویسندگان
چکیده
منابع مشابه
Cognitive and social impairment in mouse models mirrors dravet syndrome.
Commentary Dravet syndrome is an infant-onset epileptic encephalopathy characterized by generalized clonic, tonic–clonic, or hemi-clonic seizures. Patients subsequently develop other types of seizures, including myoclonic, absence, or partial seizures. Seizures are often refractory to conventional antiepileptic drugs and lack ofadequate seizure control is correlated with poor outcomes. Developm...
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Some studies have demonstrated that cognitive decline occurs in Dravet syndrome, starting shortly after the onset of seizures, rapidly progressing and then plateauing within a few years. It is unclear whether children that develop the syndrome had entirely normal cognitive skills before seizure onset, since subtle impairment easily escapes recognition in small infants. It is also difficult to d...
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Aim of the study was to describe prospectively the early neuropsychological evolution including the first pre-cognitive stages of the Severe Myoclonic Epilepsy in Infancy (SMEI) or Dravet syndrome. Five cases, four of whom since before a diagnostic evidence of the Dravet syndrome, were followed up. Full clinical assessment including developmental, visual function and behaviour assessments were ...
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Worldwide medicinal use of cannabis is rapidly escalating, despite limited evidence of its efficacy from preclinical and clinical studies. Here we show that cannabidiol (CBD) effectively reduced seizures and autistic-like social deficits in a well-validated mouse genetic model of Dravet syndrome (DS), a severe childhood epilepsy disorder caused by loss-of-function mutations in the brain voltage...
متن کاملDravet syndrome
"Dravet syndrome" (DS) previously named severe myoclonic epilepsy of infancy (SMEI), or epilepsy with polymorphic seizures, is a rare disorder characterized by an early, severe, generalized, epileptic encephalopathy.DS is characterized by febrile and afebrile seizures beginning in the 1st year of life followed by different types of seizures (either focal or generalized), which are typically res...
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ژورنال
عنوان ژورنال: Epilepsy Currents
سال: 2013
ISSN: 1535-7597,1535-7511
DOI: 10.5698/1535-7597-13.2.97